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Phenylephrine HCl affects the respiratory lining, causing it to become thin and fragmented. A nasal decongestant, found in various formulations of Mucinex, Sudafed, DayQuil / NyQuil, Alka Seltzer, and Tylenol Cold.

On September 12th, 2023 an FDA advisory committee unanimously voted in declaring oral phenylephrine an ineffective decongestant. 3 out of 4 recent studies on its efficacy show it performs no better than placebo, and the one study that supports its efficacy was conducted by its manufacturer, Glaxo Smith Kline.

Dextramethorphan HBr impacts the throat, thinning the respiratory lining. Vulnerable to viruses and bacteria. Used as a cough suppressant, and often found in various formulations of Mucinex, Dayquil and Nyquil, Alka-Seltzer, Coricidin, Delsym and Genexa.  

Of 8 recent studies on dextromethorphan, 7 found it to be ineffective in reducing cough. The sole study in support of its efficacy was funded by Proctor and Gamble, the manufacturer of Vicks.

Indicated to thin and loosen mucus, often featured in forms of Robitussin, Mucinex, Buckley’s, Bronchochem, Alka-Seltzer and Genexa.

7 out of 10 recent studies found guaifenesin unsuccessful in clearing mucus. As expected, the 3 studies claiming it does anything were all funded by Reckitt Benckiser, the manufacturer of Mucinex.

Used for pain relief and fever reduction, often found in forms of Tukol, Tylenol Cold, Sudafed PE, Dayquil and Nyquil, Alka-Seltzer, Theraflu, Sinex and Genexa.

7 out of 9 recently conducted studies show acetaminophen to prolong the common cold, and pose significant threats to liver function, with over 50% of acute liver failure stemming from acetaminophen overuse. Worse, its shown to deplete your body of its most powerful antioxidant, glutathione.

A nasal decongestant, found in various forms of Sudafed, Allegra, and Sinufrin.

3 studies found pseudoephedrine ineffective, despite its behind-the-counter exclusivity. What it DOES do is shrink the blood vessels throughout your body, not just in the sinuses, putting you at risk for high blood pressure.

A topical numbing agent, commonly found in products such as Cepacol, Hall’s, Chloraseptic, and Cofsils.

One of the more creative studies on the efficacy of benzocaine in relieving oral pain found that sucking on ice works faster and
better. It’s also not safe for use in young children.

Usually used for allergies, antihistamines are included in multi-symptom products like Nyquil and Dayquil, Coricidin, Alka Seltzer, Advil, and Robitussin.

6 recent studies show that the addition of antihistamines in multi-ingredient cold and flu products does NOT relieve runny nose or sneezing. Antihistamines treat similar allergic symptoms but are not recommended for cold or flu.The American Academy of Allergy, Asthma and Immunology and the American College of Clinical Pharmacy have asked for the removal of antihistamine decongestant-analgesic combinations from the market as a cold remedy.

An essential vitamin that features in products such as Emergen-C, Ester-C, and Airborne. After 2 days of treatment with citric acid, there was virtually no change in the tissue damage. 

We are big advocates of vitamin C for its many benefits. But there is inconclusive evidence whether it does anything for treating the common cold. 11 studies found no significant effect of Vitamin C on the duration of cold symptoms, with 10 other studies showing no significant effect on the risk of common cold.

An essential mineral featured in homeopathic products such as Zicam, Cold-Eeze, and Reboost. Zinc is useful if taken for a deficiency, as pictured below.

While we advocate using zinc as a daily supplement, its efficacy for reducing the duration of common is inconclusive.

3 studies show that zinc has no effect on the risk of common cold infection. 2 other studies show that administering zinc for upper respiratory symptoms had no impact on the duration of symptoms. There are at least 7
different forms of oral zinc, which have not been adequately studied for effectiveness.